[the world]

Diseases

From a widespread plague to the bite of a dire rat, disease is a serious threat to common folk and adventurers alike. Diseases rarely have a limited frequency, but most have a lengthy onset time. This onset time can also be variable. Most diseases can be cured by a number of consecutive saving throws or by spells such as remove disease.

The following samples represent just some of the possibilities when creating diseases.

BLIGHTBURN SICKNESS

Undead Unleashed
Type disease, contact (see text); Save Fortitude DC 22
Onset 1/day; Frequency 1/day
Effect 1d6 Con damage and 1d6 Cha damage; contact is automatic when a creature comes within a 60- foot radius of blightburn, and can be blocked only by lead sheeting, 1 foot of stone, or a force effect; Cure 2 consecutive saves
Creatures that come too close to the radioactive mineral known as blightburn risk contracting blightburn sickness.

Blinding Sickness

Type disease, ingested; Save Fortitude DC 16
Onset 1d3 days; Frequency 1/day
Effect 1d4 Str damage, if more than 2 Str damage, target must make an additional Fort save or be permanently blinded; Cure 2 consecutive saves

Bluespit

Numeria, Land of Fallen Stars
Type disease, inhaled; Save Fortitude DC 14
Onset 1 hour; Frequency 1/day
Effect 1d6 nonlethal damage and fatigue. The fatigue and nonlethal damage cannot be cured while the disease remains. This fatigue does not stack with itself to produce exhaustion, but does stack with other sources of fatigue. A victim that accumulates sufficient damage to fall unconscious while infected with bluespit begins to suffocate. Despite being unconscious, the victim is considered to be holding its breath rather than immediately progressing to negative hit points and death.
Cure 2 consecutive saves
This bacterial infection from Silver Mount thrives in avian and mammalian lungs. The name is derived from the bluetinged sputum coughed up by victims—at least until they finally keel over.

Bubonic Plague

Type disease, injury or inhaled; Save Fortitude DC 17
Onset 1 day; Frequency 1/day
Effect 1d4 Con damage and 1 Cha damage and target is fatigued; Cure 2 consecutive saves

Cackle Fever

Type disease, inhaled; Save Fortitude DC 16
Onset 1 day; Frequency 1/day
Effect 1d6 Wis damage; Cure 2 consecutive saves

Coward's Mark

Numeria, Land of Fallen Stars
Type disease, contact or inhaled; Save Fortitude DC 13
Onset 1 week; Frequency 1/day
Initial Effect 1d2 Dexterity damage and 1d2 Wisdom damage. If the victim fails two saving throws 2 days in a row (not counting the initial save), he develops a secondary effect, or the existing secondary effect worsens. Curing the affliction immediately removes all accumulated secondary effects.
Secondary Effect The first time the disease progresses, the victim becomes shaken whenever other creatures (including allies) are within 30 feet. After the second progression, the victim must succeed at a Will saving throw (DC equal to the disease's save DC) or become frightened each time any creature approaches within 30 feet. The victim needs to attempt a saving throw against any specific creature only once every 24 hours. With the third and final progression, the disease's save DC increases by 2, and the reaction upon a failed save increases to panic. After the third progression, the victim feels safe only in complete solitude. The secondary effects of coward's mark are mind-affecting fear effects.
Cure 3 consecutive saves
Externally manifesting as round marks on the skin like ringworm, this fungal infection soon spreads to the nervous system. The corpses of victims that succumb to coward's mark sprout thousands of fruiting bodies 1d4 days after death, spreading the infection on the wind.

Demon Fever

Type disease, injury; Save Fortitude DC 18
Onset 1 day; Frequency 1/day
Effect 1d6 Con damage, target must make a second Fort save or 1 point of the damage is drain instead; Cure 2 consecutive saves

Devil Chills

Type disease, injury; Save Fortitude DC 14
Onset 1d4 days; Frequency 1/day
Effect 1d4 Str damage; Cure 3 consecutive saves

DEMONPLAGUE

Type disease, injury or ingested; Save Fortitude DC 18
Onset 1 day; Frequency 1/day
Effect 1d3 Con damage and 1d6 Wis damage, and victim is fatigued if it takes any ability damage from the disease; certain creatures slain by demonplague rise as plagued beasts, Cure 3 consecutive saves

Filth Fever

Type disease, injury; Save Fortitude DC 12
Onset 1d3 days; Frequency 1/day
Effect 1d3 Dex damage and 1d3 Con damage; Cure 2 consecutive saves

Final Rest

Numeria, Land of Fallen Stars
Type disease, inhaled; Save Fortitude DC 16
Onset 1 week; Frequency 1/day
Effect 1d2 Charisma damage; while any Charisma damage remains, the victim cannot gain morale bonuses, receives a +2 bonus on saves against mind-affecting effects, and must attempt a saving throw even against harmless mind-affecting effects.
Cure 2 consecutive saves
A disease brought to Golarion from the ruined starship, final rest saps emotion until the victim simply gives up living.

Ghoul Fever

Type Bite—injury; Save Fort DC 13
Onset 1 day; Frequency 1/day;
Effect 1d3 Con and 1d3 Dex damage
Cure 2 consecutive saves

HALF-LIFE PALSY

Undead Unleashed
Type curse, disease, contact or ingested; Save Will DC 20
Onset 1d4 weeks; Frequency 1/day
Effect 1 Dex damage and 1d3 Cha damage, and any undead feeding upon the victim takes the same amount of Charisma damage that the victim has unless it succeeds at a DC 20 Will save; Cure 3 consecutive saves

Leprosy

Type disease, contact, inhaled, or injury; Save Fortitude DC 12 negates, Fortitude DC 20 to avoid effects
Onset 2d4 weeks; Frequency 1/week
Effect 1d2 Cha damage; Cure 2 consecutive saves

Mindfire

Type disease, inhaled; Save Fortitude DC 12
Onset 1 day; Frequency 1/day
Effect 1d4 Int damage; Cure 2 consecutive saves

Red Ache

Type disease, injury; Save Fortitude DC 15
Onset 1d3 days; Frequency 1/day
Effect 1d6 Str damage; Cure 2 consecutive saves

RED DRIP

Undead Unleashed
Type disease (fungus), contact; Save Fortitude DC 18
Onset 1 day; Frequency 1/day
Effect 1d4 Dex damage and 1d2 Cha damage; Cure 2 consecutive saves or amputation of infected limb

SCARLET LEPROSY

Undead Unleashed
Type disease, contact; Save Fortitude DC 20
Incubation 1 day; Frequency 1/day
Effect 1d6 Con damage and 1d6 Cha damage; whenever the character takes Con damage, 1 point is permanent drain; Cure 2 consecutive saves
The disease known as scarlet leprosy is normally carried by carrion golems, but it can also be found wherever biological waste is improperly disposed of.

Shakes

Type disease, contact; Save Fortitude DC 13
Onset 1 day; Frequency 1/day
Effect 1d8 Dex damage; Cure 2 consecutive saves

 

Shattermind

Numeria, Land of Fallen Stars
Type disease, contact; Save Will DC 17
Onset 1 day; Frequency 1/day
Effect 1d4 Wis (cannot reduce Wisdom below 1); on any day the victim fails her saving throw, she suffers the effects of a type of insanity. Unlike normal insanity, on any day she makes a successful saving throw (using the DC for shattermind, not her form of insanity), she regains her sanity for that day. A given variety of shattermind spreads the same form of insanity to all of its victims.
Cure 2 consecutive saves
Shattermind refers to a group of related infectious mental patterns spread by skin-to-skin contact between infected victims. Most forms of shattermind affect only humanoids and monstrous humanoids. Each form of shattermind spreads a different form of insanity to its victims.Restoration allows a new saving throw but does not cure the insanity.

Slimy Doom

Type disease, contact; Save Fortitude DC 14
Onset 1 day; Frequency 1/day
Effect 1d4 Con damage, target must make a second Fort save or 1 point of the damage is drain instead; Cure 2 consecutive saves